Epoxyeicosatrienoic acids (EETs) are a group of bioactive lipids derived from the polyunsaturated fatty acid arachidonic acid. Arachidonic acid is a 20-carbon fatty acid that serves as a precursor for various signaling molecules in the body. EETs are produced through the action of cytochrome P450 enzymes, particularly CYP2C and CYP2J isoforms, which convert arachidonic acid into these epoxide-containing metabolites.
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