Transition path sampling

Transition Path Sampling (TPS) is a computational technique used in statistical mechanics and molecular dynamics to study rare events, particularly transitions between different states of a system. This method is particularly useful for exploring processes that require significant energy barriers to overcome, such as conformational changes in biomolecules, chemical reactions, or phase transitions. **Key Concepts of Transition Path Sampling:** 1. **Transition Events:** TPS focuses on the trajectories (paths) that link two distinct states or configurations of a system over time.