Polycystin 1

Polycystin 1 (PC1) is a large, multi-domain protein that is primarily associated with the function of renal epithelial cells and plays a crucial role in kidney development and function. It is encoded by the PKD1 gene, and mutations in this gene are associated with autosomal dominant polycystic kidney disease (ADPKD), a condition characterized by the formation of fluid-filled cysts in the kidneys, leading to renal dysfunction.