Ion channel hypothesis of Alzheimer's disease

The Ion Channel Hypothesis of Alzheimer's Disease (AD) suggests that dysfunction in ion channels, which are crucial for maintaining the balance of ions across cell membranes, plays a significant role in the pathogenesis of AD. This hypothesis posits that the dysregulation of calcium (Ca²⁺) homeostasis, due to altered function or expression of ion channels, contributes to the neuronal cell death and synaptic dysfunction observed in Alzheimer's patients.